Wise County is a county located in the U.S. state of Virginia. The county was formed in 1856 from Lee, Scott, and Russell Counties and named for Henry A. Wise, who was the Governor of Virginia at the time. The county seat is in Wise.

Cities: Wise, Big Stone Gap, Coeburn, Pound, Appalachia, Stonega, East Stone Gap
Population: 35,421 (2022)
Area: 405 mi²
County seat: Wise
Unemployment rate: 3.8% (Jan 2024)
Congressional district: 9th
Founded: 1856